Author

Heather Shin

Calico Life Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Andreas KelleriD· 2 shared Andrew C. YangiD· 2 shared Sophia M. ShiiD· 2 shared Tony Wyss‐CorayiD· 2 shared Achint KauriD· 1 shared Agnieszka A. WendorffiD· 1 shared Andy J. ChangiD· 1 shared Astrid GillichiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Andreas KellerORCID

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3 papers

Recent·Most cited

Domain-specific proteome remodeling defines mouse myelin aging

Yarden Freund, Michael Schoof, Noa Moreno, Florian Kriegel, Heather Shin, Vanessa Waelchli, Achint Kaur, Kevin Abraham, Ido Fogel, Sophia M. Shi, Ning-Sum To, Ian Hunter Guldner, Tom H. Cheung, Andrew C. Yang, Andreas Keller, , Tal Iram

This study identifies age- and sex-related changes in the mouse myelin proteome, revealing increased structural proteins and decreased cytoskeletal and synaptic proteins with aging.

bioRxiv · Jul 9, 2026 · PreprintNeuroscience

Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging

Claire Gizowski, Galina Popova, Heather Shin, Marius Marc-Daniel Mader, Wendy Craft, Wenjun Kong, Yohei Shibuya, Bernd J. Wranik, Yan Hong Huang Fu, Constanze Depp, Tzu‐Hua Lin, Baby Martin-McNulty, Yongjin Yoo, Po-Han Tai, Maximilian Hingerl, , Oliver Hahn

This study uses heterochronic myeloid cell replacement to show that the local brain environment, not intrinsic factors, drives microglia aging.

bioRxiv · Sep 2, 2025 · PreprintNeuroscience

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease

Matthias Flotho, Andrew C. Yang, Fabian Kern, Simon Graf, Ian Ferenc Diks, Heather Shin, Kristy A. Zera, Daniela Berdnik, Maayan R. Agam, Divya Channappa, Sophia M. Shi, Malia A. Belnap, Epiphani Simmons, Karen P. Bradshaw, Friederike Grandke, , Tony Wyss‐Coray

This paper uses VINE-seq to create a vascular transcriptomic atlas in Alzheimer's disease, revealing transcriptional changes in vascular cells and identifying angiopoietin signaling as a key dysregulated pathway.

bioRxiv · Aug 25, 2025 · PreprintNeuroscience