Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair
Tsotne Chitiashvili, Alexander L. Li, Agnieszka A. Wendorff, K. Sivasubramanian, Wenjun Kong, Erik Arroyo-Colon, Ziyou Ren, Evangelia Malahias, Po-Han Tai, Georgina Duenas, John C. K. Wang, Kexin Kong, Ngoc Vu, John M. Patino, Wendy Craft, , Astrid Gillich
This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.
bioRxiv · Aug 21, 2026 · PreprintCell Biology