Author

Helen McLaughlin

Biogen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 4 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:fine-mapping· 1

Frequent Co-Authors

Eric Marshall· 3 shared Heiko RunziD· 3 shared Amanda J. GuiseiD· 2 shared Benjamin B. SuniD· 2 shared Biogen Biobank Team· 2 shared Chia‐Yen CheniD· 2 shared Jake Gagnon· 2 shared Kejie LiiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersGenetic & Genomic Medicine

Eric Marshall

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spatial transcriptomics reveals heterogeneous cell-cell interactions among brain regions in a cuprizone model consistent with multiple sclerosis lesions

Hui‐Hsin Tsai, Sarbottam Piya, Jing Wang, Jing Zhu, Wenxing Hu, Andrew R. Gehrke, Shaolong Cao, Amanda J. Guise, Su Jing Chan, Mark J. Sheehan, Jenhwa Chu, Zhengyu Ouyang, Matthew M. Ryals, Michelle Lee, Wanli Wang, , Baohong Zhang

The paper uses spatial transcriptomics to analyze cell-cell interactions in a cuprizone model, finding region-specific changes and partial translatability to multiple sclerosis lesions.

Frontiers in Bioinformatics · Aug 6, 2026Peer-reviewedNeuroscience

Comparative snRNAseq study of C9orf72, SOD1, and sALS spinal cord

Shaolong Cao, Mark J. Sheehan, Victor Cox, Dirk M. Walther, Amanda J. Guise, Edward D. Plowey, Maria I. Zavodszky, Thomas M. Carlile, Ravi Challa, Yi Chen, Guoqiang Zhang, Helen McLaughlin, Catherine L. Worth, Chia‐Yen Chen, Shih‐Ching Lo, , Dann Huh

This study compares snRNAseq data from C9orf72, SOD1, and sporadic ALS spinal cords, identifying shared and distinct molecular features across cell types.

bioRxiv · Aug 26, 2025 · PreprintNeuroscience

Loss of CFHR5 function reduces the risk for age-related macular degeneration

Mary Pat Reeve, Stephanie J. Loomis, Eija Nissilä, Thomas W. Soare, Tobias Rausch, Zhili Zheng, Pietro Della Briotta Parolo, Daniel Ben-Isvy, Elias Aho, Emilia Cesetti, Yoko Okunuki, Helen McLaughlin, Johanna Mäkelä, FinnGen, Mitja Kurki, , Heiko Runz

The paper identifies CFHR5 variants that reduce AMD risk by lowering FHR-5 levels and altering complement pathway activity.

Nature Communications · Jul 1, 2025Peer-reviewedGenetic & Genomic Medicine

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank

Robert Francis Hillary, Danni A. Gadd, Zhana Kuncheva, Tasos Mangelis, Tin-Chi Lin, Kyle L. Ferber, Helen McLaughlin, Heiko Runz, Biogen Biobank Team, Eric Marshall, Riccardo Emilio Marioni, Christopher N. Foley, Benjamin B. Sun

This study identifies gene-environment interactions affecting plasma proteins in UK Biobank, discovering 683 vQTLs and over 1,400 GEIs across 571 proteins.

Nature Communications · Aug 26, 2024Peer-reviewedGenetic & Genomic Medicine

Rare genetic variants impact muscle strength

Yunfeng Huang, Dóra Bodnár, Chia‐Yen Chen, Gabriela Sánchez-Andrade, Mark Sanderson, Biogen Biobank Team, Christopher D. Whelan, Paola G. Bronson, David Sexton, Sally John, Eric Marshall, Mehool Patel, Saranya Duraisamy, Timothy Swan, Denis A. Baird, , Heiko Runz

This study identifies six genes associated with hand grip strength using rare protein-coding variants in 340,319 individuals and shows additive effects with common variants.

Nature Communications · Jun 10, 2023Peer-reviewedGenetic & Genomic Medicine