Yi Chen

Microbial Dynamics Across Commercial Spaceflights of Varying Duration

This study examines microbiome and immune changes in astronauts after short and long-duration spaceflights, finding stable gut and oral microbiomes but transient skin microbiome shifts and immune activation.

Multi-hit STAG2 mutations define a high-risk subset of MDS and reveal convergent evolutionary targeting of cohesin

The paper identifies multi-hit STAG2 mutations in MDS patients, showing they are associated with worse outcomes and suggest convergent evolutionary targeting of the cohesin gene.

Bacteria Hijack a Host Metabolite via Three Distinct Sensors to Orchestrate Infection

This study shows bacteria use three distinct sensors to detect a host metabolite and coordinate infection, with a drug targeting one sensor showing high efficacy against resistant pathogens.

Expanding the Clinical and Molecular Spectrum of TUBB2B Through Distinct Variants Identified Across Multiple Families

The paper reports new TUBB2B variants in multiple families, expanding the clinical and molecular spectrum of tubulinopathies and highlighting phenotypic heterogeneity and dual molecular diagnoses.

Comparative snRNAseq study of C9orf72, SOD1, and sALS spinal cord

This study compares snRNAseq data from C9orf72, SOD1, and sporadic ALS spinal cords, identifying shared and distinct molecular features across cell types.

Responses of grapevine cells to physiological doses of ethanol, among which induced resistance to heat stress

This study investigates how ethanol affects grapevine cells' response to heat stress, finding ethanol-induced upregulation of heat shock proteins and enhanced heat tolerance.

A T6SS DNase effector induces nuclear DNA Damage to trigger apoptosis via activation of the cGAS-STING-TNF axis

This paper identifies TkeA, a T6SS DNase effector from Yersinia pseudotuberculosis, which induces host apoptosis via the cGAS-STING-TNF axis and promotes bacterial competition.

Pluripotent stem cell-derived NK progenitor cell therapy prevents tumour occurrence and eradicates minimal residual disease

This study develops a novel CAR-NK cell therapy using pluripotent stem cell-derived NK progenitors that persist in blood and eliminate minimal residual disease.

Soleus H-Reflex Up-Conditioning during Sciatic Nerve Regeneration in Rats Improves Recovery of Locomotion

This study shows that H-reflex up-conditioning during sciatic nerve regeneration in rats improves H-reflex recovery and locomotor symmetry, while down-conditioning has no negative effect.