Bacterial Peptidoglycan Extends Lifespan by Activating Lysosomal Activity through V-ATPase Binding
Herui Fu, Jia Tie, Yan Zhou, Xin Wang, Zhao Shan, Bin Qi
This study identifies bacterial peptidoglycan as a conserved activator of lysosomal function that extends lifespan in C. elegans and mice by enhancing V-ATPase activity and lysosomal acidification.
bioRxiv · Sep 2, 2026 · PreprintPhysiology