AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin Signaling
Hongcheng Jiang, Zi-Xuan Liu, Li Yu, Xiaodan Zhong, Yunkun Qu, Shiliang Li, Lei Dai, Ying Zhang, Mengwen Wang, Wenjun Zhang, Wanjun Liu, Xingwei He, Wei Dong, Thati Madhusudhan, Zhiyong Li, , Hesong Zeng
This study identifies integrin β3 as a key driver of aortic dissection, showing its synergy with AT1R via non-canonical Wnt/β-catenin signaling, and suggests dual-target therapy as a potential treatment.
bioRxiv · Mar 26, 2025 · PreprintPharmacology & Toxicology