Author

Wei Dong

BGI Group (China)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Genomics· 2 Cancer Biology· 1 Genetics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Aihua YiniD· 1 shared Chaonan ShiiD· 1 shared Chengguang Zhu· 1 shared Chunna Fan· 1 shared Dandan HuangiD· 1 shared Fa Chen· 1 shared Fengxia LiuiD· 1 shared H Y Ma· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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1 shared paperGenomics

Aihua YinORCID

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5 papers

Recent·Most cited

Single-cell multiomic QTL mapping reveals state-dependent genetic regulation and associated gene during cellular senescence

Xianfu Yi, Xueqi Wang, Kunlun Liu, Lin Zhao, Fa Chen, Qianting Jian, Jianhua Wang, Hao Lu, Wei Dong, Yao Zhou, Ying Chang, Xiaoqiong Gu, Pak Chung Sham, Dandan Huang, Mulin Jun Li

The paper uses single-cell multiome data to identify QTLs regulating gene expression and chromatin accessibility during cellular senescence, revealing new causal variants and regulatory mechanisms.

bioRxiv · Sep 21, 2026 · PreprintGenetics

Hepatocellular Carcinoma Revisited from Single Cell Sequencing: Dynamic Evolution from Epithelial Dedifferentiation to Mesenchymal Remodeling

Kai Yan, Wei Dong, Y Q Wu, Zhe Han, Jinling Hong, H Y Ma, Chengguang Zhu, Yangjie Xiong, Zhao Yang

This study re-analyzes single-cell RNA sequencing data to uncover dynamic cellular processes in hepatocellular carcinoma, including epithelial dedifferentiation and immune cell interactions.

bioRxiv · Apr 28, 2026 · PreprintCancer Biology

AT1R and Integrin β3 Synergize to Drive Aortic Dissection via Non-Canonical Wnt/β-Catenin Signaling

Hongcheng Jiang, Zi-Xuan Liu, Li Yu, Xiaodan Zhong, Yunkun Qu, Shiliang Li, Lei Dai, Ying Zhang, Mengwen Wang, Wenjun Zhang, Wanjun Liu, Xingwei He, Wei Dong, Thati Madhusudhan, Zhiyong Li, , Hesong Zeng

This study identifies integrin β3 as a key driver of aortic dissection, showing its synergy with AT1R via non-canonical Wnt/β-catenin signaling, and suggests dual-target therapy as a potential treatment.

bioRxiv · Mar 26, 2025 · PreprintPharmacology & Toxicology

Characterizing sensitivity and coverage of clinical WGS as a diagnostic test for genetic disorders

Yan Sun, Fengxia Liu, Chunna Fan, Yaoshen Wang, Lijie Song, Zhonghai Fang, Rui Han, Zhonghua Wang, Xiaodan Wang, Ziying Yang, Zhenpeng Xu, Jiguang Peng, Chaonan Shi, Hongyun Zhang, Wei Dong, , Zhiyu Peng

This study evaluates the sensitivity and coverage of clinical whole-genome sequencing (WGS) for detecting genetic variants, finding that 40X mean depth achieves high sensitivity for SNVs and indels but not 100%.

BMC Medical Genomics · Apr 13, 2021Peer-reviewedGenomics

Developmentally Delayed Epigenetic Reprogramming Underlying the Pathogenesis of Preeclampsia

Wei He, Yuan Wei, Xiaoli Gong, Luyuan Chang, Wan Jin, Ke Liu, Xinghuan Wang, Yu Xiao, Wenjing Zhang, Qiong Chen, Kai Wu, Lili Liang, Jia Liu, Ya–Wen Chen, Huanhuan Guo, , Aihua Yin

This study identifies epigenetic reprogramming defects in preeclampsia placenta that cause developmental delay and can be detected in serum cfDNA for early prediction.

bioRxiv · May 8, 2020 · PreprintGenomics