Apolipoprotein E4 Exacerbates Aβ Oligomer-Induced Synaptotoxicity through Promoting Autophagic Degradation of Glutathione Peroxidase 4
Jing Zhou, Hongji Liao, Wenjing Liang, Shuyi Liu, Jingjing Cai, Yu Liu, Yimei Liu, Zhonglou Zhou, Shengzhou Wu
This study shows APOE4 worsens Aβ oligomer-induced synaptotoxicity by promoting autophagic degradation of STIM1 and Gpx4, leading to mitochondrial dysfunction and synaptic loss.
bioRxiv · Nov 3, 2026 · PreprintNeuroscience