Identification of lipid senolytics targeting senescent cells through ferroptosis induction
Lei Justan Zhang, Rahagir Salekeen, Carolina Soto-Palma, Osama Elsallabi, Hongping Ye, Brian Hughes, Borui Zhang, Allancer Nunes, Kyoo-a Lee, Wandi Xu, Abdalla D. Mohamed, Ellie Piepgras, Sara J. McGowan, Luise A. Angelini, Ryan D. O'Kelly, , Paul D. Robbins
This study identifies lipid senolytics that kill senescent cells via ferroptosis, extending healthspan in mice by targeting ACSL4, LPCAT3, and ALOX15.
Cell Press Blue · Feb 26, 2026Peer-reviewedCell Biology