Author

Brian Hughes

University of Minnesota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Abdalla D. MohamediD· 3 shared Allancer NunesiD· 3 shared Carolina Soto-PalmaiD· 3 shared Laura J. NiedernhoferiD· 3 shared Lei Justan ZhangiD· 3 shared Luise A. Angelini· 3 shared Osama ElsallabiiD· 3 shared Paul D. RobbinsiD· 3 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Abdalla D. MohamedORCID

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Author profile →

3 papers

Recent·Most cited

Identification of lipid senolytics targeting senescent cells through ferroptosis induction

Lei Justan Zhang, Rahagir Salekeen, Carolina Soto-Palma, Osama Elsallabi, Hongping Ye, Brian Hughes, Borui Zhang, Allancer Nunes, Kyoo-a Lee, Wandi Xu, Abdalla D. Mohamed, Ellie Piepgras, Sara J. McGowan, Luise A. Angelini, Ryan D. O'Kelly, , Paul D. Robbins

This study identifies lipid senolytics that kill senescent cells via ferroptosis, extending healthspan in mice by targeting ACSL4, LPCAT3, and ALOX15.

Cell Press Blue · Feb 26, 2026Peer-reviewedCell Biology

Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair

Lei Justan Zhang, Osama Elsallabi, Carolina Soto-Palma, Josh Bartz, Rahagir Salekeen, Allancer Nunes, Wandi Xu, Kyooa Lee, Brian Hughes, Borui Zhang, Abdalla D. Mohamed, Sara J. McGowan, Luise A. Angelini, Ryan D. O'Kelly, Seyed Ali Biashad, , Paul D. Robbins

This study identifies fucoidans as senotherapeutics that enhance SIRT6-dependent DNA repair and reduce senescence in aged mice.

bioRxiv · Apr 27, 2025 · PreprintCell Biology

Development of novel flavonoid senolytics through phenotypic drug screening and drug design

Lei Justan Zhang, Rahagir Salekeen, Carolina Soto-Palma, Yuanjun He, Osama Elsallabi, Brian Hughes, Allancer Nunes, Wentao Xu, Borui Zhang, Abdalla D. Mohamed, Sara J. McGowan, Luise A. Angelini, Ryan D. O'Kelly, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins

This study develops two novel flavonoid senolytics through phenotypic drug screening and design, showing enhanced senolytic activity and healthspan extension in a mouse model.

bioRxiv · Oct 27, 2024 · PreprintCell Biology