Unraveling single-molecule reactions via multiplexed in-situ DNA sequencing
Jagadish Prasad Hazra, Rebecca Andrews, Piers Turner, Qing Zhao, Horst Steuer, Afaf Helmy El-Sagheer, Abhishek Mazumder, Hafez El Sayyed, Mirjam Kümmerlin, Tom P Brown, Achillefs N. Kapanidis
This paper introduces SPIN-Seq, a method that links DNA sequence with functional properties at the single-molecule level, revealing sequence-dependent transcription factor interactions and RNA polymerase behavior.
Nature Communications · Aug 29, 2026Peer-reviewedBiophysics