A methylome-derived m6-dAMP trigger assembles a PUA-Cal-HAD immune filament that depletes dNTPs to abort phage infection
Zhiying Zhang, Yi Wu, Yan‐Jiun Lee, Gianlucca Gonçalves Nicastro, Arpita Chakravarti, Hui Fang, D. Taverner, Peter Weigele, Lakshminarayanan Aravind, Dinshaw J. Patel, Franklin L. Nóbrega
The paper identifies a methylome-derived m6-dAMP trigger that forms an immune filament in E. coli to deplete dNTPs and abort phage infection.
bioRxiv · Jan 16, 2026 · PreprintMicrobiology