Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids
Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, Morgan J. Robinson, Harish Kothandaraman, Ye-Eun Yoo, Iria G. Dopeso‐Reyes, Thomas D Buffenoir, Manasi Suchit Halurkar, Hui Yang, Zaiyang Zhang, Muhan Wang, Erin N Creager, Harris D. Giles, Yuanrui Zhao, , Yang Yang
This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.
Neuron · Sep 1, 2026Peer-reviewedNeuroscience