Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging
S. S. Saeedi Saravi, B. Pugin, F. Constancias, A. Thomas, S. Le Gludic, M. S. Allemann, G. Karsai, P. Lee, C. Menni, I. Attaye, J. H. Beer
This study shows that gut microbiota-dependent phenylacetic acid (PAA) increases endothelial cell senescence and impairs angiogenesis in aging, with acetate able to reverse these effects.
bioRxiv · Nov 17, 2023Cell Biology