P. Lee

The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo

This study examines how neutrophils affect bacteriophage clearance and pharmacokinetics in mice, finding minimal impact from neutrophils but significant inactivation of phages over time.

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging

This study shows that gut microbiota-dependent phenylacetic acid (PAA) increases endothelial cell senescence and impairs angiogenesis in aging, with acetate able to reverse these effects.

Territorial aggression in male bower-building cichlids Nyassachromis cf. microcephalus is disrupted by exposure to environmental concentrations of fluoxetine

This study shows that fluoxetine exposure reduces territorial aggression in male cichlid fish, suggesting environmental serotonin disruption affects behavior.

Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA

The study assesses the prevalence of Bourbon and Heartland viruses in ticks at an environmental field station, finding 3.9% and 7.6% positivity rates respectively.

Simulated poaching affects global connectivity and efficiency in social networks of African savanna elephants - an exemplar of how human disturbance impacts group-living species

This paper simulates poaching effects on African savanna elephant social networks, showing that removing socially central individuals reduces network connectivity and efficiency.

Discovery of imidazole-based inhibitors of P. falciparum cGMP-dependent protein kinase

The paper identifies imidazole-based inhibitors of PfPKG with good potency and low hERG activity against multiple Plasmodium species.

Discovery of novel potent, cell-permeable inhibitors of P. falciparum cGMP-dependent protein kinase.

The paper reports the discovery and optimization of novel PfPKG inhibitors with good potency, low hERG activity, and anti-parasitic activity.

An epigenetic switch regulates the ontogeny of AXL positive/EGFR-TKI resistant cells by modulating miR-335 expression

The paper identifies an epigenetic mechanism regulating AXL-positive/Erlotinib-resistant cells through miR-335 expression, suggesting combinatorial therapies for EGFR-mutated NSCLC.

Relative contribution of non-structural protein 1 in dengue pathogenesis

This study shows that NS1 does not play a critical role in pathogenesis of certain DENV2 strains, suggesting NS1 may not be a universal vaccine candidate.

Analysis of Mammalian Succinate Dehydrogenase Kinetics and Reactive Oxygen Species Production

This study develops a computational model of succinate dehydrogenase to identify the mechanisms of superoxide and hydrogen peroxide production under various conditions.

Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus Strains

This study identifies genetic polymorphisms in reovirus strains that influence their oncolytic potency by affecting replication and host-cell signaling pathways.

Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation

This study shows that Ly6G ligation selectively inhibits β2 integrin-dependent neutrophil migration in specific inflammatory contexts.