BiophysicsbioRxiv
Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP
A. Götz, P. Högel, M. Silber…·D. Langosch
This study examines how the I45T mutation in APP affects H-bond stability and ε-cleavage efficiency, leading to altered Aβ levels in familial Alzheimer’s disease.
DOI 10.1038/s41598-019-41766-1