Author

C. Muhle-Goll

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

M. Silber· 3 shared B. Luy· 2 shared C. Scharnagl· 2 shared D. Langosch· 2 shared A. Goetz· 1 shared A. Götz· 1 shared A. Vogel· 1 shared D. Huster· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiophysics

M. Silber

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 19, 2021

Cleavage of PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state

V. Siebert, M. Silber, E. Heuten…·M. K. Lemberg

This study identifies key residues and structural features in PGAM5 that determine its cleavage by PARL, showing that membrane potential uncoupling affects its oligomeric state and processing.

DOI 10.1101/2021.11.19.469224

experimental assay

𝕏 PostBluesky

BiophysicsbioRxivNov 20, 2018

Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage

A. Goetz, N. Mylonas, P. Hoegel…·H. Steiner

The paper shows that altering the flexibility of a di-glycine hinge in the APP transmembrane domain affects γ-secretase cleavage and specificity.

DOI 10.1016/j.bpj.2019.04.030

experimental assay

𝕏 PostBluesky

BiophysicsbioRxivAug 4, 2018

Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP

A. Götz, P. Högel, M. Silber…·D. Langosch

This study examines how the I45T mutation in APP affects H-bond stability and ε-cleavage efficiency, leading to altered Aβ levels in familial Alzheimer’s disease.

DOI 10.1038/s41598-019-41766-1

humanexperimental assay

𝕏 PostBluesky