Author

M. Silber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

C. Muhle-Goll· 3 shared B. Luy· 2 shared C. Scharnagl· 2 shared D. Langosch· 2 shared A. Goetz· 1 shared A. Götz· 1 shared A. Vogel· 1 shared D. Huster· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiophysics

C. Muhle-Goll

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3 papers

Recent·Most cited

Cleavage of PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state

V. Siebert, M. Silber, E. Heuten, C. Muhle-Goll, M. K. Lemberg

This study identifies key residues and structural features in PGAM5 that determine its cleavage by PARL, showing that membrane potential uncoupling affects its oligomeric state and processing.

bioRxiv · Nov 19, 2021 · PreprintCell Biology

Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage

A. Goetz, N. Mylonas, P. Hoegel, M. Silber, H. Heinel, S. Menig, A. Vogel, H. Freyrer, D. Huster, B. Luy, D. Langosch, C. Scharnagl, C. Muhle-Goll, F. Kamp, H. Steiner

The paper shows that altering the flexibility of a di-glycine hinge in the APP transmembrane domain affects γ-secretase cleavage and specificity.

bioRxiv · Nov 20, 2018Biophysics

Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP

A. Götz, P. Högel, M. Silber, I. Chaitoglou, B. Luy, C. Muhle-Goll, C. Scharnagl, D. Langosch

This study examines how the I45T mutation in APP affects H-bond stability and ε-cleavage efficiency, leading to altered Aβ levels in familial Alzheimer’s disease.

bioRxiv · Aug 4, 2018Biophysics