Mycolactone enhances the Ca2+ leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state
P. Bhadra, S. Dos Santos, I. Gamayun, T. Pick, J. Ogbechi, B. S. Hall, R. Zimmermann, V. Helms, R. E. Simmonds, A. Cavalie
This study shows mycolactone enhances Ca2+ leakage from the ER by trapping Sec61 translocons in a Ca2+ permeable state, leading to ER Ca2+ depletion.
bioRxiv · May 12, 2021Biochemistry