R. Zimmermann

A precision microgel platform to direct vascular morphogenesis in vitro

This paper introduces a microgel platform that precisely controls morphogen gradients to guide vascular morphogenesis in vitro.

Cold exposure induces dynamic changes in circulating triacylglycerol species, which is dependent on intracellular lipolysis: a randomized cross-over trial

This study shows cold exposure increases circulating free fatty acids and transiently lowers total triacylglycerols in humans, with dynamic changes in TAG species dependent on saturation and chain length, and this effect is mediated by intracellular lipolysis.

Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

This study shows that SCD1 inhibits Treg differentiation and promotes autoimmunity by affecting fatty acid metabolism in an MS model.

Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting

The paper identifies substrates and a novel component, hSnd3, in the hSnd2-dependent ER protein targeting pathway through proteomic analysis.

Dissecting the conformational complexity and flipping mechanism of a prokaryotic heme transporter

The paper identifies CydDC as a heme flippase essential for cytochrome bd maturation, revealing its conformational mechanism through cryo-EM and molecular dynamics.

Lipid droplets control mitogenic lipid mediator production in human cancer cells

The paper shows lipid droplets regulate mitogenic lipid mediator production in cancer cells by controlling PUFAs availability through ATGL and DGAT1.

Mycolactone enhances the Ca2+ leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

This study shows mycolactone enhances Ca2+ leakage from the ER by trapping Sec61 translocons in a Ca2+ permeable state, leading to ER Ca2+ depletion.

Proteomics identifies signal peptide features determining the substrate specificity in human Sec62/Sec63-dependent ER protein import