Inhibitors of ROCK kinases induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
J. Martino, S. O. Siri, N. S. Paviolo, C. Garro, M. F. Pansa, S. Carbajosa, A. Brown, J. L. Bocco, I. Gloger, G. Drewes, K. P. Madauss, G. Soria, V. Gottifredi
This paper shows that ROCK kinase inhibitors induce synthetic lethality in BRCA2-deficient cells through mitotic defects, independent of DNA damage.
bioRxiv · Jun 24, 2022Cancer Biology