Cancer BiologybioRxiv
Inhibitors of ROCK kinases induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells
J. Martino, S. O. Siri, N. S. Paviolo…·V. Gottifredi
This paper shows that ROCK kinase inhibitors induce synthetic lethality in BRCA2-deficient cells through mitotic defects, independent of DNA damage.
DOI 10.7554/elife.80254