Author

I. Graupera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Blasco-Roset· 1 shared A. Giorgetti· 1 shared A. Moles· 1 shared A. Navarro-Gascon· 1 shared A. P. Arruda· 1 shared A. Planavila· 1 shared A. Woodhoo· 1 shared A. Zorzano· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

A. Blasco-Roset

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Author profile →

2 papers

Recent·Most cited

Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

R. A. Martinez Garcia de la Torre, J. Vallverdu, Z. Xu, S. Arino, B. Aguilar-Bravo, P. Ruiz Blazquez, M. Fernandez Fernandez, A. Navarro-Gascon, A. Blasco-Roset, P. Sanchez--Fernandez-de-Landa, J. Pera Garcia, D. Romero-Moya, P. Ayuso Garcia, C. Martinez Sanchez, L. Zanatto, , P. Sancho-Bru

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

bioRxiv · Feb 15, 2024Cell Biology

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity

R. L. S. Goncalves, Z. B. Wang, K. E. Inouye, Y. G. Lee, X. Fu, J. Saksi, C. Rosique, G. Parlakgul, A. P. Arruda, T. S. Hui, M. C. Loperena, S. C. Burgess, I. Graupera, G. S. Hotamisligil

The paper shows that ubiquinone deficiency in obesity leads to reverse electron transport, increasing mROS and disrupting hepatic metabolic homeostasis.

bioRxiv · Feb 21, 2023 · PreprintBiochemistry