X. Fu

Confidence-Enhanced Semi-supervised Learning for Mediastinal Neoplasm Segmentation

This paper introduces a confidence-enhanced semi-supervised learning framework for mediastinal neoplasm segmentation, improving performance by leveraging unlabeled data and refining prediction reliability.

Label-Free Electrochemical Imaging of Single Extracellular Vesicles

This paper introduces a label-free technique to quantify single extracellular vesicles by measuring their electrochemical impedance, enabling differentiation between cancerous and healthy cell-derived vesicles.

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice

This study shows that transferring gut microbiota from young and estropausal mice improves ovarian function and fertility in adult mice.

Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

This study identifies human CD29+/CD56+ myogenic progenitors with tendon differentiation potential that improve tendon repair when transplanted.

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

This study shows BRD8 maintains pluripotency by sensing and maintaining histone acetylation, preventing the conversion of primed EpiSCs to naive ESCs.

Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity

This paper identifies a shear-dependent interaction between Protein S and von Willebrand Factor that reduces free PS anticoagulant activity and contributes to thrombotic risk in viral infections.

Simultaneous Identification of Changepoints and Model Parameters in Switching Dynamical Systems

This paper introduces a method to simultaneously estimate changepoints and model parameters in switching dynamical systems, demonstrating its effectiveness through simulations and a real-world COVID-19 case study.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

The Mechanism Insight into Bacterial Degradation of Pentachlorobiphenyl

This study identifies a new bacterium capable of degrading pentachlorobiphenyl and characterizes its enzymatic, proteomic, and metabolomic responses to the pollutant.

ArborSim: Articulated, branching, OpenSim routing for constructing models of multi-jointed appendages with complex muscle-tendon architecture

ArborSim constructs musculoskeletal models of complex jointed structures with branching muscle-tendon architectures, revealing that branching affects kinematics more than parallel structures.

Deciphering the diversity and sequence of extracellular matrix and cellular spatial patterns in lung adenocarcinoma using topological data analysis

This study uses topological data analysis to quantify ECM architecture and spatial patterns in lung adenocarcinoma, revealing progressive changes linked to immune exclusion and metabolic shifts.

Sc-TUSV-ext: Single-cell clonal lineage inference from single nucleotide variants (SNV), copy number alterations (CNA) and structural variants (SV)

Sc-TUSV-ext improves clonal lineage reconstruction by integrating SNV, CNA, and SV from single-cell DNA sequencing data, showing better accuracy on synthetic and real data.

Mutation divergence over space in tumour expansion

This study quantifies how mutation divergence varies with sampling distance and tumour expansion modes using simulations, showing that mutation rate inference is less accurate with smaller sampling sizes and slower expansion.

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

Force sensing GPR133 is essential for normal balance and modulates vestibular hair cell membrane excitability via Gi signaling and CNGA3 coupling

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

The amino acid sequence determines protein abundance through its conformational stability and reduced synthesis cost.

This study shows that amino acid sequences determine protein abundance by affecting conformational stability and synthesis cost, using deep learning and yeast experiments.

Edible fire buffers: mitigation of wildfire with multifunctional landscapes

This paper demonstrates that banana buffers can mitigate wildfires, generate profit, and provide ecosystem services, even under climate change.

HDAC4-mediated deacetylation of GSDMD prevents pyroptosis by inhibiting GSDMD ubiquitination

This study identifies HDAC4-mediated deacetylation of GSDMD as a mechanism to inhibit pyroptosis by preventing GSDMD ubiquitination.

Lipase-mediated detoxification of host-derived antimicrobial fatty acids by Staphylococcus aureus

This study identifies Lip2 as a Staphylococcus aureus lipase that detoxifies antimicrobial fatty acids via esterification with cholesterol, revealing its role in skin colonization resistance.

Computational Scoring and Experimental Evaluation of Enzymes Generated by Neural Networks

The paper evaluates computational metrics for predicting enzyme activity in sequences generated by three models and finds that existing metrics like sequence identity and AlphaFold2 scores are not predictive.

Epigenetic modifications mediate cultivar-specific root development and metabolic adaptation to nitrogen availability in wheat

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity

The paper shows that ubiquinone deficiency in obesity leads to reverse electron transport, increasing mROS and disrupting hepatic metabolic homeostasis.

Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts

This study shows that increasing HDAC6 activity impairs mitochondrial complex I in diabetic hearts subjected to ischemia/reperfusion, and that inhibiting HDAC6 improves cardiac function.

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-mediated gluconeogenesis in mice

This study investigates how liver mitochondrial pyruvate carrier deficiency affects de novo lipogenesis and glycerol-mediated gluconeogenesis in mice, finding impaired DNL but no reduction in intrahepatic lipid and unchanged glucose levels despite reduced glycerol metabolism.

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

Computational structure prediction methods enable the systematic identification of oncogenic mutations

This paper introduces a computational method to identify oncogenic mutations by integrating evolutionary information and protein structure prediction, demonstrating its effectiveness in pediatric leukemias.

Systematic mining and functional analysis of factors regulating wheat spike development for breeding selection

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

Deletion of 12-lipoxygenase normalizes platelet function after storage and transfusion in thrombocytopenic mice

This study shows that deleting 12-LOX improves post-transfusion function of stored murine platelets by altering fatty acid and oxylipin profiles.

Characterizing the Resolution and Throughput of the Apollo Direct Electron Detector

The paper evaluates the Apollo direct electron detector's performance in cryo-EM, showing high-resolution reconstructions across different dose rates and sample sizes.