Z. Xu

A Conserved Geometric Code: Extracellular Matrix Curvature Directs Cell Migration Strategy via Nuclear Mechanosensing

The paper shows ECM curvature directs cell migration through nuclear mechanosensing, revealing a geometric code influencing migration strategy and metastasis.

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance

This study identifies a non-enzymatic role of ABHD6 in regulating selective hepatic insulin resistance and MASLD through interaction with the Akt-FoxO1 axis.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy

The paper shows that mTORC1 signaling hypersensitivity to leucine drives an onco-circuit in T cell malignancy, and a low leucine diet is therapeutic without impairing T cell immunity.

Molecular basis for the activation of the Fatty Acid Kinase complex of Staphylococcus aureus

This study investigates the structure and function of the Fatty Acid Kinase complex in Staphylococcus aureus using modeling, biochemical, and cell-based approaches, revealing key residues and interactions essential for its activity.

Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy

This study reveals the conformational landscape of soluble α-klotho using cryo-EM, showing flexibility and multiple forms that support its FGFR-independent functions.

The TCRs of pathogenic Th17 cells in arthritogenic mice are shifted toward a Treg-like repertoire

The paper shows that ZAP-70 mutations in mice lead to a shift in T cell repertoires, with pathogenic Th17 cells resembling Tregs and contributing to autoimmune arthritis.

Study of Impacts of Two Types of Cellular Aging on the Yeast Bud Morphogenesis

This study analyzes two aging modes in yeast, showing spherical budding cells better control growth and size, and develops a model to test mechanisms of bud morphogenesis during aging.

Design and optimization of novel succinate dehydrogenase inhibitors against agricultural fungi based on Transformer model

This study uses a Transformer model to design novel succinate dehydrogenase inhibitors against agricultural fungi, resulting in potent antifungal compounds through virtual screening and optimization.

Highly efficient in vivo mutagenesis method based on the endonuclease and exonuclease activity of Bacillus alcalophilus RecJ (BaRecJ)

This paper introduces a novel mutagenesis method using BaRecJ's endonuclease and exonuclease activities, showing broader mutation spectra and improved trait-associated gene identification in E. coli and S. cerevisiae.

TLR9 activation in large wound induces tissue repair and hair follicle regeneration via gamma delta T cells

This study shows that TLR9 activation in wounds promotes tissue repair and hair follicle regeneration through gamma delta T cells by increasing AREG production and modulating keratinocyte fate.

Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

Mathematical Modelling Indicates Th-cell Targeted Antibody-Dependent Cellular Cytotoxic Is a Crucial Obstacle Hurdling HIV Vaccine Development

This paper uses mathematical modeling to show that ADCC targeting Th cells hinders HIV vaccine development by damaging immune responses and reducing vaccine effectiveness.

Modeling reveals the strength of weak interactions in stacked ring assembly

The paper develops a mathematical model of stacked trimer assembly, revealing that strong interaction affinities can lead to kinetic trapping, suggesting evolutionary pressure for weaker interactions in stacked ring structures.

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

This study identifies low tumorous magnesium content as a driver factor of colorectal cancer by showing its impact on gene mutations, EMT activation, and cell migration through DBN1 phosphorylation.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

Enzyme Fragment Complementation Driven by Nucleic Acid Hybridization

This paper introduces a biosensor for detecting nucleic acid interactions using modified protein fragment complementation with NanoBiT fragments conjugated to steramers.

Re-coding of G protein-coupled receptor signaling enables emergent cellular behavior.

The paper shows that co-expression of G protein-coupled receptors can lead to emergent cellular behavior through a switch in downstream signaling, specifically demonstrating a reversal of dopamine D2 receptor activity.

Comparison of chronic aerosol inhalation with combustible cigarette and e-cigarette on the psychiatric behaviors and neuroimmune profile in mice

This study compares the effects of combustible cigarette and e-cigarette aerosol inhalation on psychiatric behaviors and neuroimmune profiles in mice, finding greater anxiety in combustible cigarette exposure.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Landscape and functional repertoires of long noncoding RNAs in the pan-cancer tumor microenvironment using single-nucleus total RNA sequencing

The paper maps lncRNA landscapes across ten cancer types using single-nucleus RNA sequencing and identifies cell type-specific lncRNA-mRNA pairs and regulatory networks.

Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the Mucor species complex

This study identifies Erg3 and Erg6a as key enzymes in the ergosterol biosynthetic pathway of Mucor circinelloides, showing their roles in antifungal drug resistance and virulence.

An automated archival single-nucleus total RNA sequencing platform mapping integrative and retrospective cell atlas of gliomas

This paper introduces an automated single-nucleus RNA sequencing platform for analyzing archival glioma samples, revealing molecular characteristics and recurrence-related targets.

MiceVAPORDot: A novel automated approach for high-throughput behavioral characterization during E-cigarette exposure in mice

MiceVAPORDot automates behavioral analysis during e-cigarette exposure in mice, revealing phenotypes not detectable by traditional methods.

Rhodococcus equi Escapes Macrophage Autophagy: VapA Inhibits ATP6V0d1-Mediated Lysosomal Degradation

This study shows that VapA from Rhodococcus equi inhibits macrophage autophagy by blocking ATP6V0D1, allowing the bacteria to escape lysosomal degradation.

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

SARS-CoV-2 Omicron BA.2.86: less neutralization evasion compared to XBB sub-variants

This study compares the immune evasion of SARS-CoV-2 Omicron BA.2.86 to XBB sub-variants, finding BA.2.86 shows less neutralization evasion.

Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

Osteoclast-Cancer Cell Metabolic Symbiosis Renders PARP Inhibitor Therapy Resistance in Bone Metastasis

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.

A reverse-central-dogma pathway underlies ribosome-antibiotic efficacy and accelerates resistance evolution

This study reveals a reverse-central-dogma pathway by which ribosome antibiotics cause genomic instability and accelerate resistance evolution through transcription-translation coupling disruption.