Mutational landscape and in silico structure models of SARS-CoV-2 Spike Receptor Binding Domain reveal key molecular determinants for virus-host interaction
S. Nelson-Sathi, P. K. Umasankar, S. Easwaran, R. R. Nair, I. Joseph, S. R. C. Nori, J. S. Philip, R. Prasad, K. V. Navyasree, S. Ramesh, H. Pillai, S. Gosh, S. K. TR, M. R. Pillai
The paper analyzes mutations in SARS-CoV-2 Spike RBD across 31,403 genomes, identifies key molecular determinants for RBD-ACE2 binding, and proposes implications for vaccine and therapeutic design.
bioRxiv · May 2, 2020Evolutionary Biology