S. Ramesh

TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.

Generative Adversarial Networks Accurately Reconstruct Pan-Cancer Histology from Pathologic, Genomic, and Radiographic Latent Features

This paper introduces HistoXGAN, a GAN that reconstructs cancer histology from latent features, showing it retains tumor grade, histologic subtype, and gene expression patterns across 29 cancer types.

MET Inhibitor Capmatinib Radiosensitizes MET Exon 14-Mutated and MET-Amplified Non-Small Cell Lung Cancer

This study shows that capmatinib radiosensitizes MET exon 14-mutated and MET-amplified NSCLC cells and tumors, inhibiting DNA repair and reducing tumor growth.

Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor

This study identifies immune cell types and biomarkers in irMyocarditis using single-cell RNA sequencing and TCR analysis across heart, blood, and tumor tissues.

Validating a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning

The paper validates a low-cost, open-source workstation and computational pipeline for automated histopathology evaluation using deep learning, showing comparable performance to expensive institutional hardware.

McrD binds asymmetrically to methyl-coenzyme M reductase improving active site accessibility during assembly

The paper structurally characterizes intermediate states of methyl-coenzyme M reductase (MCR) assembly, revealing McrD's role in facilitating F430 cofactor installation.

Comparing scientific abstracts generated by ChatGPT to original abstracts using an artificial intelligence output detector, plagiarism detector, and blinded human reviewers

This paper evaluates ChatGPT-generated scientific abstracts against original ones using AI detectors, plagiarism tools, and human reviewers, finding they are original but identifiable as AI-generated.

Self-supervised deep learning for pan-cancer mutation prediction from histopathology

This paper develops a self-supervised deep learning pipeline to predict genetic mutations from histopathology images across seven cancer types in two large datasets.

CNTNAP4 signaling regulates osteosarcoma disease progression

This study shows that CNTNAP4 signaling promotes osteosarcoma progression, and its deletion reduces tumor growth, angiogenesis, and metastasis.

Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors

This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.

Mutational landscape and in silico structure models of SARS-CoV-2 Spike Receptor Binding Domain reveal key molecular determinants for virus-host interaction

The paper analyzes mutations in SARS-CoV-2 Spike RBD across 31,403 genomes, identifies key molecular determinants for RBD-ACE2 binding, and proposes implications for vaccine and therapeutic design.