R. Prasad

Amino Acid-Dependent Material Properties of Tetrapeptide Condensates

This study investigates how different amino acids affect the physical properties of tetrapeptide condensates, revealing significant variations in phase behavior and material properties.

Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B

This study evolves two clade II Candida auris isolates to develop amphotericin B resistance, revealing distinct mechanisms and intra-clade heterogeneity in resistance acquisition.

ATP Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks

This study shows ATP mediates phase separation of basic intrinsically disordered proteins by acting as bridges between protein chains, forming liquid-like droplets with unique physical properties.

Evidence that metastases arise de novo as new cancers from cells of target organs

The paper shows that metastases form de novo in target organs when chromatin particles from dying cancer cells transform local cells into new cancers.

Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis

This study shows that disrupting soluble epoxide hydrolase (sEH) in the liver prevents abdominal aortic aneurysm (AAA) formation by reducing inflammatory factors like C3 and SAA.

A Common Pathway for Detergent-Assisted Oligomerization of Aβ42

This study identifies a common oligomerization pathway for Aβ42 stabilized by SDS and DPC micelles, revealing structural and stabilizing mechanisms.

Dimeric Transmembrane Structure of the SARS-CoV-2 E Protein

The paper determines the dimeric structure of the SARS-CoV-2 E protein using NMR and simulations, identifying a hydrophobic pore and potential drug-binding site.

Inhibition of miR-214 expression by small molecules alleviates head and neck cancer metastasis by targeting ALCAM/TFAP2 signaling.

This study shows that inhibiting miR-214 with EGCG reduces head and neck cancer metastasis by targeting ALCAM/TFAP2 signaling.

Differentially deregulated microRNAs contribute to ultraviolet radiation-induced photocarcinogenesis through immunomodulation: An-analysis of microRNAs expression profiling.

This study identifies differentially expressed miRNAs in UVB-induced skin cancer and shows their role in immunomodulation and photocarcinogenesis.

Structural Model for Self-Limiting β-strand Arrangement Within an Alzheimer's Amyloid-β Oligomer

The paper presents a structural model of an Alzheimer's Aβ42 oligomer based on solid-state NMR and cryo-EM data, explaining its stability and ion permeability.

SpiDec: Computing Binodals and Interfacial Tension of Biomolecular Condensates From Simulations of Spinodal Decomposition

SpiDec computes binodals and interfacial tension of biomolecular condensates from spinodal decomposition simulations of intrinsically disordered proteins.

Spontaneous suppressors against debilitating transmembrane mutants of CaMdr1 disclose novel interdomain communication via Signature motifs of the Major Facilitator Superfamily

The paper identifies novel interdomain communication mechanisms in the MFS superfamily by analyzing suppressor mutations of a drug-resistant mutant of CaMdr1.

Genome-wide analysis of PTR/POT transporters in Candida species and their functional characterization in the newly emerged pathogen Candida auris

The paper identifies and characterizes PTR transporters in five Candida species, finding two distinct classes and showing their role in di-/tripeptide uptake and drug resistance in C. auris.

Genomic landscape of the DHA1 family in the newly emerged pathogen Candida auris and mapping substrate repertoire of the prominent member CauMdr1

This study maps the DHA1 family in Candida auris and identifies substrates of CauMdr1, showing overexpression increases antifungal resistance.

Plausible Mechanistic Insights in Biofilm Eradication Potential of against Candida spp. using In Situ Synthesized Tyrosol Functionalized Chitosan Gold Nanoparticles as a versatile Antifouling Coating on Implant Surfaces

This study evaluates the antifungal and antibiofilm effects of tyrosol functionalized chitosan gold nanoparticles against Candida species and identifies mechanisms of action.

Radiation-reprogrammed glioma stem cells generate vascular-like cells to build a trophic niche driving tumor recurrence

The paper shows radiation induces vascular-like phenotypes in glioma stem cells, creating a trophic niche that promotes tumor recurrence, and identifies P300 inhibition as a potential therapeutic strategy.

Plasma microbiome in COVID-19 subjects: an indicator of gut barrier defects and dysbiosis

The paper analyzes plasma microbiome and permeability markers in COVID-19 patients and healthy controls, finding higher gut permeability and gram-negative bacteria abundance in patients.

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivity.

This study identifies sol-SorCS1 as a soluble form of SorCS1 that enhances insulin sensitivity by binding the insulin receptor, improving glucose uptake and signaling in myocytes.

Mutational landscape and in silico structure models of SARS-CoV-2 Spike Receptor Binding Domain reveal key molecular determinants for virus-host interaction

The paper analyzes mutations in SARS-CoV-2 Spike RBD across 31,403 genomes, identifies key molecular determinants for RBD-ACE2 binding, and proposes implications for vaccine and therapeutic design.

Membrane Association and Functional Mechanism of Synaptotagmin-1 in Triggering Vesicle Fusion

This study uses molecular dynamics simulations to show how Ca2+-bound synaptotagmin-1 facilitates vesicle fusion by interacting with both vesicle and plasma membranes through its C2 domains.

Allelopathic effect of Anogeissus pendula Edgew. and Grewia flavescens A.Juss on Desmodium species in Alwar district of Rajasthan

This study evaluates the allelopathic effects of leaf leachates from Anogeissus pendula and Grewia flavescens on three Desmodium species, finding reduced seed germination and radicle/plumule elongation.

ERBB2 and KRAS Alterations Mediate Response to EGFR Inhibitors in early stage Gallbladder Cancer

This study identifies ERBB2 and KRAS mutations in early-stage gallbladder cancer and shows their impact on response to EGFR inhibitors.