PhysiologybioRxiv
Trans-endothelial insulin transport is impaired in skeletal muscle capillaries of obese male mice.
I. M. Williams, P. M. McClatchey, D. P. Bracy…·D. H. Wasserman
This study shows that diet-induced obesity in male mice impairs trans-endothelial insulin transport, reduces endothelial vesicle density, and leads to skeletal muscle insulin resistance despite maintained interstitial insulin delivery.
DOI 10.1002/oby.22683