An instructive role for IL7RA in the development of human B-cell precursor leukemia.
I. Geron, A. M. Savino, N. Tal, H. Fishman, J. Brown, V. Turati, C. James, J. Sarno, Y. N. Lee, A. Rein Gil, Y. Birger, I. Muler, M. Hameiri-Grossman, V. Marcu-Malina, O. Parnas, , S. Izraeli
This study shows that aberrant IL7RA signaling in human hematopoietic progenitors leads to B-cell differentiation arrest and Ph-like BCP-ALL development in mice.
bioRxiv · Jan 27, 2020 · PreprintCancer Biology