Author

C. James

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 7 Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 9 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Research Focus:gene regulatory network inference· 3 Assay:ATAC-seq· 2

Frequent Co-Authors

G. Caravagna· 5 shared J. Fernandez-Mateos· 5 shared A. Sottoriva· 4 shared A.-M. Baker· 4 shared B. Chen· 4 shared C. Kimberley· 4 shared D. Shibata· 4 shared G. D. Cresswell· 4 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

G. Caravagna

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments

A. Verma, V. Pandey, C. Sherry, C. James, K. Matteson, J. T. Smith, A. Rudkouskaya, X. Intes, M. Barroso

This study uses fluorescence lifetime imaging to quantify TZM-HER2 binding and distribution in tumors with varying microenvironments, showing differences in drug delivery efficacy between cancer types.

bioRxiv · Jan 12, 2024Cancer Biology

Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping

J. Fernandez-Mateos, S. Milite, E. Oliveira, G. Vlachogiannis, B. Chen, E. Yara, G. D. Cresswell, C. James, L. Patruno, G. Ascolani, A. Acar, T. Heide, I. Spiteri, A. Graudenzi, G. Caravagna, , A. Sottoriva

The paper shows how epigenetic heritability of cell plasticity contributes to cancer drug resistance through a one-to-many genotype-to-phenotype mapping.

bioRxiv · Nov 15, 2023 · PreprintCancer Biology

High Resolution Biological and Physical Sampling Reveals Expression of Domoic Acid Biosynthetic Genes at Frontal Zones

M. Thukral, A. T. Aron, A. J. Rabines, D. Petras, C. M. Preston, H. Zheng, Z. Fussy, C. James, W. Ussler, A. J. Lucas, C. R. Anderson, C. A. Scholin, P. C. Dorrestein, J. P. Ryan, A. E. Allen

This study combines high-resolution physical and multi-omic sampling to identify DA biosynthetic gene expression in frontal zones of Monterey Bay during declining upwelling.

bioRxiv · Oct 19, 2023 · PreprintMicrobiology

Phosphorylation-dependent interactions of VAPB and ELYS contribute to the temporal progression of mitosis

R. H. Kehlenbach, C. James, U. Möller, S. König, H. Urlaub

This study identifies phosphorylation-dependent interactions between VAPB and ELYS that facilitate nuclear envelope formation during mitosis.

bioRxiv · Jul 3, 2023 · PreprintCell Biology

Phenotypic plasticity and genetic control in colorectal cancer evolution

J. Househam, T. Heide, G. D. Cresswell, C. Lynn, I. Spiteri, M. Mossner, C. Kimberley, C. Gabbutt, E. Lakatos, A. Berner, M. Schmidt, A.-M. Baker, J. Fernandez-Mateos, B. Chen, L. Zapata, , T. A. Graham

This study investigates phenotypic plasticity and genetic control in colorectal cancer by analyzing gene expression and genetic variation across multiple tumor regions.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

The co-evolution of the genome and epigenome in colorectal cancer

T. Heide, J. Househam, I. Spiteri, C. Lynn, G. D. Cresswell, M. Mossner, C. Kimberley, J. Fernandez-Mateos, B. Chen, L. Zapata, C. James, I. Barozzi, K. Chkhaidze, D. Nichol, A. Berner, , A. Sottoriva

This study examines the co-evolution of genome and epigenome in colorectal cancer using single-clone spatial multi-omic profiling, revealing epigenetic changes and their impact on mutation accumulation.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

T. Heide, J. Househam, G. D. Cresswell, I. Spiteri, C. Lynn, C. Kimberley, M. Mossner, L. Zapata, C. Gabbutt, D. Ramazzotti, B. Chen, J. Fernandez-Mateos, C. James, F. Iorio, A. Berner, , A. Sottoriva

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

bioRxiv · Jul 14, 2021 · PreprintCancer Biology

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

W. Cross, S. Nowinski, G. Cresswell, M. Mossner, A. Banerjee, B. Lu, M. Williams, G. Vlachogiannis, L. Gay, A.-M. Baker, C. Kimberley, F. Whiting, H. Belnoue-Davis, P. Martinez, M. Traki, , Wat

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

bioRxiv · Mar 26, 2020 · PreprintCancer Biology

An instructive role for IL7RA in the development of human B-cell precursor leukemia.

I. Geron, A. M. Savino, N. Tal, H. Fishman, J. Brown, V. Turati, C. James, J. Sarno, Y. N. Lee, A. Rein Gil, Y. Birger, I. Muler, M. Hameiri-Grossman, V. Marcu-Malina, O. Parnas, , S. Izraeli

This study shows that aberrant IL7RA signaling in human hematopoietic progenitors leads to B-cell differentiation arrest and Ph-like BCP-ALL development in mice.

bioRxiv · Jan 27, 2020 · PreprintCancer Biology

Generation and Trapping of a Mesoderm Biased State of Human Pluripotency

D. Stavish, C. Boiers, C. Price, T. J. R. Frith, J. Halliwell, I. Barbaric, J. Brown, J. Carr, C. James, P. W. Andrews, T. Enver

The paper identifies and traps a mesoderm-biased pluripotent state in human stem cells using WNT signaling and lysophosphatidic acid.

bioRxiv · Oct 24, 2019Cell Biology