Modelling glioblastoma resistance to temozolomide. Combination of spheroid and mathematical models to simulate cellular adaptation in vitro.
M. Perez-Aliacar, J. Ayensa-Jimenez, T. Randelovic, I. Ochoa, M. Doblare
This paper combines 3D glioblastoma spheroid experiments with mathematical models to simulate temozolomide resistance and understand cellular adaptation mechanisms.
bioRxiv · Nov 24, 2023 · PreprintCancer Biology