Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy
M. Verweij, S. G. Hansen, R. Iyer, N. John, D. Malouli, D. Morrow, I. Scholz, J. Womack, S. Abdulhaqq, R. M. Gilbride, C. M. Hughes, A. B. Ventura, J. C. Ford, A. N. Selseth, K. Oswald, , K. Früh
This study shows that the Rh67/UL40 protein in RhCMV/SIV vectors is necessary for MHC-E-restricted CD8+ T cell responses and SIV protection in rhesus macaques.
bioRxiv · Sep 30, 2020Immunology