R. Iyer

Novel antibody language model accelerates IgG screening and design for broad-spectrum antiviral therapy

This paper introduces an antibody language model (AbLM) to accelerate IgG screening and design for broad-spectrum antiviral therapy, achieving higher precision in predicting variant-resistant antibodies.

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

This paper designs short, target-binding linear peptides using a contrastive learning framework, demonstrating effective binding and degradation of conformationally diverse proteins.

Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence.

This study uses whole genome sequencing of Borrelia burgdorferi isolates to identify plasmid-borne accessory genome elements linked to virulence and dissemination of Lyme disease.

Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy

This study shows that the Rh67/UL40 protein in RhCMV/SIV vectors is necessary for MHC-E-restricted CD8+ T cell responses and SIV protection in rhesus macaques.

Biocontrol of Aspergillus niger in 3D-lung cell tissues by oxalotrophic bacteria

This study shows oxalotrophic bacteria inhibit Aspergillus niger's pathogenicity by limiting oxalic acid production and restoring pH in 3D-lung cell cultures.

Predicting Brain Age Using Structural Neuroimaging and Deep Learning

This paper develops deep learning models to predict brain age from structural MRI data and finds that predicted brain age differs between cognitively impaired and healthy individuals of similar chronological age.

Comparing DNA, RNA and protein levels for measuring microbial activity in nitrogen-amended soils

The paper compares DNA, RNA, and protein levels to assess microbial activity in nitrogen-amended soils, finding that RNA best correlates with nitrification activity while DNA and proteins show limited correlation.