Folding of mRNA-DNA origami for controlled translation and viral vector packaging
I. Seitz, S. Saarinen, J. Wierzchowiecka, J. J. L. M. Cornelissen, V. Linko, M. A. Kostiainen
This study investigates how design parameters affect mRNA-DNA origami folding and translation efficiency, showing the importance of ribosome-binding sequences and demonstrating their encapsulation in virus capsids for enhanced delivery.
bioRxiv · May 29, 2024Bioengineering