Author

V. Linko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:clustering· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:gene regulatory network inference· 1 Assay:multiome· 1

Frequent Co-Authors

M. A. Kostiainen· 4 shared H. Ijäs· 2 shared I. Seitz· 2 shared A. Heuer-Jungemann· 1 shared A. Keller· 1 shared A. Klose· 1 shared B. Shen· 1 shared E. Anaya-Plaza· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBioengineering

M. A. Kostiainen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Fluorescence Anisotropy Analysis of the Interaction between Doxorubicin and DNA Origami Nanostructures

E. S. Lisitsyna, A. Klose, E. Vuorimaa-Laukkanen, H. Ijäs, T. Lajunen, K. Suhling, V. Linko, T. Laaksonen

This paper uses fluorescence anisotropy to study DOX-DON interactions, showing complex formation, homo-FRET, and aggregation at high loading ratios, with implications for nanocarrier design.

bioRxiv · Jun 20, 2024 · PreprintBiochemistry

Folding of mRNA-DNA origami for controlled translation and viral vector packaging

I. Seitz, S. Saarinen, J. Wierzchowiecka, J. J. L. M. Cornelissen, V. Linko, M. A. Kostiainen

This study investigates how design parameters affect mRNA-DNA origami folding and translation efficiency, showing the importance of ribosome-binding sequences and demonstrating their encapsulation in virus capsids for enhanced delivery.

bioRxiv · May 29, 2024Bioengineering

Reconfigurable pH-Responsive DNA Origami Lattices

S. Julin, V. Linko, M. A. Kostiainen

This paper demonstrates a pH-responsive DNA origami lattice that can be reversibly switched between states using pH changes, with applications in forming reconfigurable 2D gold nanoparticle lattices.

bioRxiv · Feb 3, 2023Bioengineering

DNA origami directed virus capsid polymorphism

I. Seitz, E.-P. Kumpula, E. Anaya-Plaza, J. J. Cornelissen, V. Linko, J. T. Huiskonen, M. A. Kostiainen

This paper demonstrates DNA origami-directed polymorphism of viral capsids, showing control over shape, size, and topology through programmable assembly platforms.

bioRxiv · Nov 7, 2022Bioengineering

Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release

H. Ijäs, B. Shen, A. Heuer-Jungemann, A. Keller, M. A. Kostiainen, T. Liedl, J. A. Ihalainen, V. Linko

This study characterizes and optimizes doxorubicin loading into DNA origami nanostructures, revealing rapid binding and variable release profiles influenced by nanostructure design and environmental factors.

bioRxiv · May 13, 2020Biochemistry