Author

E.-P. Kumpula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. T. Huiskonen· 3 shared A. Eesmaa· 1 shared A. J. Lopez· 1 shared A. Niemela· 1 shared A. S. Koivuniemi· 1 shared E. Anaya-Plaza· 1 shared H. Han· 1 shared I. Kursula· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiophysics

J. T. Huiskonen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structure and Interactions of the Endogenous Human Commander Complex

S. Laulumaa, E.-P. Kumpula, J. T. Huiskonen, M. Varjosalo

This study determines the structure of the endogenous human Commander complex using cryo-EM and proteomics, revealing its asymmetric organization and novel interactions involved in cellular processes.

bioRxiv · Apr 3, 2023Biophysics

DNA origami directed virus capsid polymorphism

I. Seitz, E.-P. Kumpula, E. Anaya-Plaza, J. J. Cornelissen, V. Linko, J. T. Huiskonen, M. A. Kostiainen

This paper demonstrates DNA origami-directed polymorphism of viral capsids, showing control over shape, size, and topology through programmable assembly platforms.

bioRxiv · Nov 7, 2022Bioengineering

Mechanistic insights into the activation of lecithin-cholesterol acyltransferase in therapeutic nanodiscs composed of apolipoprotein A-I mimetic peptides and phospholipids

L. Giorgi, A. Niemela, E.-P. Kumpula, O. Natri, P. Parkkila, J. T. Huiskonen, A. S. Koivuniemi

This study investigates how apoA-I mimetic peptides modulate LCAT activity in nanodiscs through molecular dynamics simulations and experiments, revealing structural and functional insights.

bioRxiv · Jun 9, 2022Biophysics

MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α

V. Kovaleva, L.-Y. Yu, L. Ivanova, J. Nam, A. Eesmaa, E.-P. Kumpula, J. Huiskonen, P. Lindholm, M. H. Voutilainen, M. Karelson, M. Saarma

This study identifies MANF's mechanism of action through its interaction with IRE1α, showing it modulates UPR and protects neurons from ER stress.

bioRxiv · Sep 22, 2020 · PreprintCell Biology

Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and phosphate release

E.-P. Kumpula, A. J. Lopez, L. Tajedin, H. Han, I. Kursula

The paper investigates the structural mechanisms of Plasmodium actin polymerization, ATP hydrolysis, and phosphate release using crystallography, revealing how the A-loop regulates filament stability.

bioRxiv · Nov 9, 2018Biochemistry