Alternative splicing in neuroblastoma generates RNA-fusion transcripts and is associated with vulnerability to spliceosome inhibitors
Y. Shi, V. Rraklli, E. Maxymovitz, S. Li, I. Westerlund, O. B. Reina, J. Yuan, P. Bullova, C. C. Juhlin, A. Stenman, C. Larsson, P. Kogner, M. J. O'Sullivan, S. Schlisio, J. Holmberg
This study identifies splicing-dependent RNA-fusions in neuroblastoma and shows spliceosome inhibition reduces tumor growth.
bioRxiv · Jan 31, 2020 · PreprintCancer Biology