J. Yuan

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

This study develops a super-resolution imaging and analysis method to study ER dynamics in Arabidopsis under environmental stress, revealing correlations between ER structure parameters and growth features.

This study shows melatonin reduces bladder fibrosis by inhibiting the TGF-β1/Smad pathway and epithelial-mesenchymal transition (EMT) in both in vitro and in vivo models.

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

CryoSTAR uses atomic models as constraints to improve cryo-EM reconstruction of conformational heterogeneity, showing better results across multiple datasets.

This study identifies RBPm1 as a splicing activator essential for axoneme assembly in Plasmodium male gametogenesis, revealing an intron splicing program critical for male development.

The paper identifies an entropic charge separation mechanism that limits coarsening in nanoscale condensates, explaining their long-term stability.

This study reveals how the small protein MgrB inhibits the sensor kinase PhoQ, modulating bacterial virulence and antimicrobial peptide sensing.

This study investigates how Escherichia coli uses potassium concentration changes for chemotaxis, revealing distinct responses from two chemoreceptors and linking potassium sensing to intracellular pH changes.

This paper engineers Saccharomyces cerevisiae to produce vanillin from glucose, achieving the highest reported titer through genetic modifications and metabolic optimization.

The paper investigates the light response mechanisms in mosses by analyzing phytochrome mutants, finding distinct roles for different phytochrome clades in sensing red and far-red light.

This study identifies Plasmodium EB1's unique MT-lattice binding role in facilitating spindle-kinetochore lateral attachment during male gametogenesis, essential for proper chromosome segregation and parasite transmission.

The paper identifies eEF2 as a prognostic biomarker for dense connective tissue repair outcomes and shows it regulates cellular processes to improve healing.

The paper identifies germline-determined quantitative trait loci (dQTLs) that influence somatic mutational features in prostate cancer, revealing their impact on tumor epigenome, transcriptome, and proteome.

This study identifies elevated protein synthesis as a critical requirement for neonatal B cell development, regulated by LIN28B and dependent on IL-7 signaling.

The paper measures the bending stiffness of the bacterial flagellar hook under counterclockwise and clockwise rotations, finding it doubles under clockwise rotation.

This study identifies molecular and genetic mechanisms underlying the transition from dioecy to monoecy in Diospyros oleifera using genome-wide analyses of 150 accessions.

The paper introduces M3-Seq, a single-cell RNA-sequencing platform for bacteria, and demonstrates its ability to reveal rare populations and stress response strategies.

The paper identifies distinct functions of VEGFA from different cell types in skeletal muscle regeneration through time-resolved transcriptomic analysis and functional experiments.

This paper investigates the distinct roles of Nrf1 and Nrf2 in the reductive stress response to DTT, showing differential regulation of redox and ER stress defense genes.

This study uses GWAS to identify 277 candidate genes associated with adventitious rooting in Populus trichocarpa, highlighting roles in hormone signaling, cell division, and reactive oxygen species.

This study uses GWAS to identify candidate genes regulating in planta regeneration in Populus trichocarpa, finding over 200 genes involved in cell adhesion, stress signaling, and hormone pathways.

This paper introduces a high-throughput plant phenotyping system with a GUI and SGIOS algorithm to streamline training data generation and improve GWAS for trait variation analysis.

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

The paper identifies IMC proteins in Plasmodium yoelii and shows DHHC2 palmitoylates CDPK1 and GAP45 for their localization, essential for schizont development.

This paper reports the high-titer production of aromatic amines in engineered E. coli by optimizing carbon source and deleting fermentation byproduct genes.

This paper develops a Saccharomyces cerevisiae-based biosensor for copper ion detection with reduced noise and improved signal output, using colorimetric and olfactory outputs for on-site monitoring.

This study directly measures the stall torque of E. coli flagellar motors using magnetic tweezers, finding each stator unit passes 2 protons per step.

This study identifies Prevotella histicola as a protective agent against estrogen-deficiency induced bone loss via the gut microbiota-bone axis in mice.

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.