S. Li

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

The paper profiles immune cell RNA and protein expression across tissues and age to identify tissue-specific and age-related immune signatures.

Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity

This study uses scRNA-seq to show that DMD satellite cells have molecular impairments and altered differentiation trajectories, leading to reduced regenerative capacity, with autophagy induction potentially rescuing differentiation.

Aerobic methane production by methylotrophic Methylotenera in groundwater

The paper identifies Methylotenera ecotypes in methane-rich groundwater that use methylphosphonate for aerobic methane production, suggesting phosphate limitation in these environments.

ClpP-dependent protein quality control supports antibiotic persistence in Campylobacter jejuni through bioenergetic homeostasis

This study identifies ClpP-dependent proteostasis as critical for antibiotic persistence in C. jejuni through bioenergetic homeostasis and metabolic remodeling.

The evolutionary cost of homophily: social stratification facilitates stable variant coexistence and increased rates of evolution in host-associated pathogens

This study shows that host population social stratification increases pathogen strain diversity by creating balancing selection pressures that support stable viral coexistence.

Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

The paper shows apoptotic caspases cleave DRP1 to induce mitochondrial fusion and enhance anti-viral immunity during viral infections.

Temporal-spatially metabolic reprogramming rewires the H3K27ac landscape to enable the initiation of liver regeneration

This study identifies metabolic reprogramming and its impact on the H3K27ac epigenetic landscape during liver regeneration.

Elraglusib induces cytotoxicity via direct microtubule destabilisation independently of GSK3 inhibition

Elraglusib causes cytotoxicity by directly destabilizing microtubules, leading to mitotic arrest, DNA damage, and apoptosis, independent of GSK3 inhibition.

Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention

This paper identifies mCMQ069, a novel antimalarial with potential for single-dose cure and one-month chemoprevention, showing improved pharmacokinetic properties over KAF156.

A new yeast-based bioreporter for simple, sensitive, and cost-effective detection of dioxin-like compounds

This study develops a yeast-based bioreporter, DnaSc, for sensitive and cost-effective detection of dioxin-like compounds and AhR agonists with a detection limit of 10 fM for TCDD.

Single-cell RNA Sequencing Reveals Methamphetamine Inhibits the Liver Immune Response with Involvement of the Dopamine D1 Receptor

This study uses single-cell RNA sequencing to show that chronic methamphetamine exposure alters liver immune cell composition and function, with involvement of the dopamine D1 receptor.

Molecular basis of Ad5-nCoV Vaccine-Induced Immunogenicity

This study investigates the molecular basis of Ad5-nCoV vaccine-induced immunogenicity by analyzing the structure and properties of the spike antigens it induces.

Molecular Architecture of Monkeypox Mature Virus

This study uses cryo-ET and STA to reveal the architecture of mature MPXV particles and identifies irregular virions with distorted core walls.

Digital Immunoassay for Rapid Detection of SARS-CoV-2 Infection in a Broad Spectrum of Animals

This paper develops a digital immunoassay for rapid detection of SARS-CoV-2 antibodies in multiple animal species with high sensitivity and specificity.

Multi-dimensionality of tree communities structure host-parasitoid networks and their phylogenetic composition

The paper examines how tree diversity and canopy cover affect host-parasitoid community composition and interaction networks in a subtropical tree biodiversity experiment.

Single-Cell Transcriptomic Analysis Highlights Specific Cell Types of Wheat Manipulated by Fusarium graminearum Leading to Susceptibility

This study uses single-cell RNA sequencing to analyze wheat cell responses to adapted and non-adapted fungal pathogens, identifying specific cell types involved in susceptibility and resistance.

Cold seeps are hotspots of deep-sea nitrogen-loss driven by microorganisms across 21 phyla

This study identifies cold seeps as significant nitrogen-loss hotspots, revealing diverse microbial communities and active nitrogen-loss genes across multiple phyla.

Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

This study shows that a single inhibitory Ly49 receptor is sufficient to license NK cells and mediate missing-self recognition in vivo.

Enrichment of glycoRNAs using galactose oxidase, hydrazide chemistry, and glycosidase digestion

The paper develops and optimizes methods to enrich and identify glycoRNAs, demonstrating efficient digestion and preservation techniques for studying their role in immune responses and disease.

A Peptide Derived from Sorting Nexin 1 Inhibits HPV16 Entry, Retrograde Trafficking, and L2 Membrane Spanning

This study shows that the peptide SNX1.3 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning, without affecting cell proliferation or post-Golgi trafficking.

A longitudinal atlas of post-viral lung regeneration reveals persistent injury-associated cell states

This study maps the temporal sequence of mouse lung regeneration after viral injury, identifying persistent injury-associated cell states and their role in alveolar niche repair.

IP3R1 is required for meiotic progression and embryonic development by regulating mitochondrial calcium and oxidative damage

This study shows that IP3R1 knockdown in porcine oocytes disrupts ER-mitochondria calcium signaling, leading to oxidative stress and impaired meiotic progression and embryonic development.

CRISPR Double Knockout Library Reveals Synthetic Lethal Gene Pairs in Triple-Negative Breast Cancer

Identifying Novel Therapeutic Targets for Overcoming TNBC Chemo Resistance Through Comprehensive CRISPR-Cas9 Genome Screening

This study uses CRISPR-Cas9 and RNAseq to identify novel synthetic lethal targets in TNBC cells resistant to cisplatin/doxorubicin, highlighting potential drug targets for combination therapies.

Gradual labeling with fluorogenic probes for MINFLUX nanoscopy of densely packed structures

This paper introduces GLF-MINFLUX, a method for nanoscale imaging of densely packed structures, achieving improved localization precision and faster acquisition.

Genome Assembly of Docynia delavayi Provides New Insights into α-Farnesene Biosynthesis

This study reports the first high-quality genome of Docynia delavayi and identifies key genes and transcription factors involved in α-farnesene biosynthesis, a major aroma compound in its fruit.

CD74+ fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloid

This study identifies CD74+ fibroblasts as key drivers of stretch-induced keloid progression through proliferation, angiogenesis, and migration.

Glutamate (E299) is a key residue in the evolutionarily divergence of the SAM-dependent methyltransferases DnrK and RdmB in anthracycline biosynthesis

The paper identifies residue E299 as critical for the divergent catalytic functions of DnrK and RdmB in anthracycline biosynthesis, revealing distinct mechanisms for 10-hydroxylation and 4-O-methylation.

Flat-field superresolution structured illumination microscopy with joint temporal-spatial light modulation

This paper introduces a flat-field structured illumination microscopy method to improve field uniformity and enable large-scale imaging of whole cells and pathological samples.