Pharmacological intervention targeting neuroimmune axis in the aging hypothalamus prevents age-associated physiological decline
Min‐Jong Seok, Nakyung Lee, In-Seop Sim, Jumi Kim, Kelvin Pieknell, Thor D. Stein, Jung-Hee Lee, Hoon Ryu, Seung-Hyup Song, Je-Kyung Seong, Il-Yong Kim, Eun Ha Ko, Yanuar Alan Sulistio, Sang Hun Lee
This study identifies the CCL3/4-CCR5 axis as a therapeutic target to delay aging by inhibiting T cell infiltration in the hypothalamus.
bioRxiv · Jan 12, 2026 · PreprintNeuroscience