The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging
Hung R. Vuong, Qianzi Zhou, Sydney L. Lesko, Kasyap Tenneti, Keanu Davis, Shanyqua Scott, Moming Guo, Daphne Boodwa-Ko, Jenna E. Eschbach, Kamya Gopal, Jessica M. Porter, Qibo Wang, Ming Xia, Anthony Twumasi Boateng, Yiqing Wang, , Sebla B. Kutluay
This study shows that the adenosine-rich content of the HIV-1 genome is critical for efficient packaging, as demonstrated by Gag-SRSF5 chimera experiments.
Proceedings of the National Academy of Sciences · Apr 2, 2026Peer-reviewedMicrobiology