Hidden stop codons orchestrate mRNA fate by ambushing ribosomal frameshifting associated with codon usage
Zhanbiao Li, Xiaoqian Gu, Shimin Gong, Zeyu Wang, Qin Bian, Ziqing Wang, ingyang Li, Shunkai Chen, Fei Li, Dan Wang, Xiuwen Li, Chuqiao Han, Xiao Liu, Qun Hu, Guiping Ren, , Yunkun Dang
The paper shows hidden stop codons promote mRNA decay by causing ribosomal frameshifting in fungi and human cells, disrupting circadian rhythms and stabilizing mRNAs with nonoptimal codons.
bioRxiv · Jan 15, 2026 · PreprintMolecular Biology