Fei Li

Valine Engages a Prefrontal mGluR5 Allosteric Site to Preserve Social Behavior

The paper shows valine modulates mGluR5 in the prefrontal cortex to preserve social behavior through an allosteric mechanism.

PAXIP1-PAGR1 directs cohesin recruitment during break-induced telomere repair

The paper identifies PAXIP1-PAGR1 as essential for cohesin recruitment during break-induced telomere repair and shows their role in ALT-mediated telomere maintenance.

Reconstructing living materials as a computable design space with multi-agent reasoning

This paper introduces LiveMat, a framework that transforms literature into a computable design space for living materials, improving reasoning across domains.

LysinFusion: Integrating Multi-Feature Encoding and Hybrid CNN-Transformer Architecture for Phage Lysin Prediction

LysinFusion improves phage lysin prediction using a hybrid CNN-Transformer model, achieving higher accuracy and fewer false positives than existing methods.

Hidden stop codons orchestrate mRNA fate by ambushing ribosomal frameshifting associated with codon usage

The paper shows hidden stop codons promote mRNA decay by causing ribosomal frameshifting in fungi and human cells, disrupting circadian rhythms and stabilizing mRNAs with nonoptimal codons.

Neural correlates of device-based sleep characteristics in adolescents

The paper identifies sleep-brain dimensions and biotypes in adolescents using device-based sleep data and imaging, linking them to cognitive and academic outcomes.

GeneCompass: Deciphering Universal Gene Regulatory Mechanisms with Knowledge-Informed Cross-Species Foundation Model

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.

Chromatin Accessibility Reveals Potential Prognostic Value of the Peak Set Associated with Smoking History in Patients with Lung Adenocarcinoma

The paper identifies ATAC-seq peaks associated with smoking history in lung adenocarcinoma that correlate with patient survival and are linked to key oncogenic pathways.