Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging
Emre Caglayan, Ishaan Lamba, Monica Devi Manam, Benjamin Finander, Lovelace J. Luquette, David Exposito-Alonso, Sijing Zhao, Bowen Jin, Michael B. Miller, Peter J. Park, Chet C. Sherwood, Christopher A. Walsh
The paper compares somatic mutation rates and transcriptomic changes in neurons across six mammalian species, finding higher mutation accumulation and distinct age-related dysregulation in human neurons.
bioRxiv · Sep 24, 2026 · PreprintNeuroscience