Gene therapy with doxycycline-controlled expression of human Kv1.1 reduces neuronal excitability and increases sociability of Scn2a-deficient mice
Brody A. Deming, Jingliang Zhang, Iuliia Vitko, Ronald Petrus Albertus Gaykema, Manasi Suchit Halurkar, Zaiyang Zhang, Akila D. Abeyaratna, Rineet Ranga, Purba Mandal, Kathryn Lund, Keeley Farmer, Deepti Ramasamy, Edward Perez‐Reyes, Yang Yang
This study shows that inducing Kv1.1 expression in Scn2a-deficient mice reduces neuronal hyperexcitability and improves sociability without affecting wild-type mice.
bioRxiv · Sep 24, 2026 · PreprintNeuroscience