Purba Mandal

The paper identifies molecular and physiological differences between asymptomatic Alzheimer's disease brains and Alzheimer's disease brains that correlate with cognitive resilience.

This study shows that inducing Kv1.1 expression in Scn2a-deficient mice reduces neuronal hyperexcitability and improves sociability without affecting wild-type mice.

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

This study develops a human neuronal chimera model to study Alzheimer's tau pathology, showing human-specific vulnerability and recapitulating mature AD features in vivo.

The paper identifies preserved mitochondrial bioenergetics in asymptomatic Alzheimer's disease brains and suggests NAD+ precursor interventions could maintain cognitive function despite pathology.

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.