Author

J. Bonin

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Biophysics· 1

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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A. Lee· 1 shared P. Sapienza· 1 shared

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2022-2022 · peak 1/yr

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1 shared paperBiophysics

A. Lee

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1 paper

Recent·Most cited

Dynamic allostery in substrate binding by human thymidylate synthase

J. Bonin, P. Sapienza, A. Lee

This study investigates the mechanism of substrate binding cooperativity in human thymidylate synthase using NMR experiments, revealing that rigidification and N-terminal interactions drive entropically-driven cooperativity.

bioRxiv · May 16, 2022Biophysics