High-level ceftazidime-avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated beta-lactamase CMY-185 variant
W. C. Shropshire, B. T. Endres, J. Borjan, S. L. Aitken, W. C. Bachman, C. L. McElheny, A. Khan, M. M. Bhatti, P. Saharasbhojane, A. Kawai, R. K. Shields, S. A. Shelburne, Y. Doi
The paper identifies a novel CMY-185 beta-lactamase variant in E. coli that confers high-level resistance to ceftazidime-avibactam through specific amino acid substitutions.
bioRxiv · Feb 3, 2023Microbiology