Y. Doi

Evolution of extended-spectrum β-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years

This study tracks the evolution of ST131 E. coli over 15 years at a single hospital, identifying dominant subclades and genetic adaptations associated with ESBL production.

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection

The paper identifies a capsule defect in K. pneumoniae that enhances complement-mediated opsonophagocytosis and persistence during recurrent infections.

Identification of a novel MCR-1 variant displaying low level of co-resistance to β-lactam antibiotics that uncovers a potential novel antimicrobial peptide

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

High-level ceftazidime-avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated beta-lactamase CMY-185 variant

The paper identifies a novel CMY-185 beta-lactamase variant in E. coli that confers high-level resistance to ceftazidime-avibactam through specific amino acid substitutions.

A Compensatory RNase E Variation Increases Iron Piracy and Virulence in Multidrug-Resistant Pseudomonas aeruginosa during Macrophage Infection

This study shows that a compensatory RNase E mutation in P. aeruginosa increases siderophore production and macrophage ferroptosis, contributing to virulence and potentially being targeted by gallium therapy.

Genomic epidemiology revealed the emergence and worldwide dissemination of ST383 carbapenem-resistant hypervirulent Klebsiella pneumoniae and hospital acquired infections of ST196 Klebsiella quasipneumoniae in Qatar

This study identifies the emergence and global spread of ST383 carbapenem-resistant hypervirulent Klebsiella pneumoniae and hospital-acquired ST196 K. quasipneumoniae in Qatar through genomic analysis.

Prediction of Resistant Mutations against Upcoming ALK-TKIs, Repotrectinib (TPX-0005) and Ensartinib (X-396)

The paper predicts resistant mutations against new ALK-TKIs, repotrectinib and ensartinib, using an error-prone PCR-based system, suggesting their potential as second-line treatments after alectinib.

Carbapenem-Resistant Acinetobacter baumannii in US hospitals: diversification of circulating lineages and antimicrobial resistance

This study analyzes CRAb isolates from US hospitals using WGS, identifying new sub-lineages and resistance patterns, highlighting shifts in CRAb population structure and clinical impact.

Genomic and functional characterization of Pseudomonas aeruginosa-targeting bacteriophages isolated from hospital wastewater

This study isolates and characterizes 14 new Pseudomonas aeruginosa-targeting phages from hospital wastewater and evaluates their antibacterial activity against clinical isolates and biofilms.

Differential ampicillin/ceftriaxone susceptibility among diverse Enterococcus faecalis from infective endocarditis

This study examines antimicrobial susceptibility of E. faecalis isolates from infective endocarditis, finding reduced ceftriaxone activity in strains with PBP4 and IreP mutations.

Dissecting the clonality of I1 plasmids using ORF-based binarized structure network analysis of plasmids (OSNAp)

The paper analyzes the clonality of I1 plasmids carrying ESBL genes using OSNAp, finding clonal patterns for some genes and diversity for others.

Comparative analysis of antigen-specific anti-SARS-CoV-2 antibody isotypes in COVID-19 patients

This study compares antigen-specific antibody isotypes in COVID-19 patients to assess their kinetics, sensitivity, specificity, and correlation with neutralizing activity.

Clinical and genomic epidemiology of carbapenem-non-susceptible Citrobacter spp. at a tertiary healthcare center over two decades

The paper analyzes the clinical and genomic epidemiology of carbapenem-non-susceptible Citrobacter spp. over two decades, finding increased prevalence and genetic diversity with carbapenemase-encoding plasmids.

Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing based molecular epidemiological study

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.